Decade of Discovery : Wellcome Trust/DBT India Alliance

you I am working on antibacterial nanomaterials to tackle the problems of bacterial infections in 2012 we found at saqqara wings have certain nano pillars that can kill the bacterial cell in this fellowship I propose that I will make surfaces which are inspired from these in cycling structures so I have made nano pillars on artificial substrates which kill the bacteria cells on contact I'm really excited about this project because it combines microbiology and nano fabrication and I think this nanotechnology has applications in many industries so I am particularly interested in this healthcare industry because the infections are so severe that people are dying and they have a significant economic impact India lines has helped me a lot because it has given me a platform where I am able to perform as an early career researchers because there's none like it in India the Alliance happened because the Wellcome Trust individual scientists and the department of biotechnology want to look at a new paradigm where we create an excitement about cutting-edge science the great strength of what we do in we work with me funk-defied technology so we know we have buy-in from the indian government and that gives enormous reassurance for any tax refund online welcome these partnerships are very important to build not only our research collaborations but also to help in building capacities for our researchers and young students and to leave rich the strength on the other side the purpose of India Alliance is to fund the best talent in biomedical research and to nurture them for future leadership roles we found a very broad range of biomedical research from basic to clinical to public health research I do research mostly in the area of maternal and child health especially in the vulnerable communities we are calling them vulnerable because their nutritional status is poor and this is despite the fact that they have enormous traditional knowledge about the indigenous foods their edibility which maybe the rest of the world is unaware of so my idea is using local foods with traditional diets in improving the nutritional status of the community understanding the gaps why it is not translating into consumption how those gaps can be addressed through policy interventions in basic research for example we fund things like causes of disease mechanisms of disease and in clinical research we confirm these hypotheses in human patients my name is Vikram I'm a physician scientist I work mainly in the area of leukemias but cancers I'm basically looking at mechanisms of drug resistance in acute promyelocytic leukemia we're talking about a blood cancer which from diagnosis to death without treatment is two to three weeks it's a very unique and very distinctive kind of a blood cancer which we treat with arsenic trioxide but it's also one of the blood cancers where if you do initiate treatment rapidly the chances of cure are the highest among all the blood cancers we've actually treated patients with very positive pulmonary results which we need to validate with larger a number of patients and the leads that we have got with this we believe we can take forward in looking at ways in which we can treat other blood cancers as well we are also an agency that wants to set pace in policy issues and one of the issues that we have taken up recently is women in science I'm a population geneticist they've been working on tigers and their population genetics for about a decade now our goal is to investigate how important genetic variation is to individual well-being so does it matter to the Tigers at random or does it affect their futures if they are genetically deep operates or wrongful go Tigers are just an example of what's happening to many populations across the world of many species as human population density increases wild spaces shrink and you have few individuals 50 to 100 animals which are in these islands habitat Islands and so over time as it becomes harder for individuals to move between these parks because there are seas of people in between we have to address whether it's okay to let these small populations be or are the inbreeding effects going to kick in and those populations may go extinct in which case we have to think about whether we need to supplement them genetically I'm trying to use this research as an example to think of what might be the best strategy to secure futures and minimize extinction and I hope that insights from studying ranthambore will be generalizable to other species and situations our fellowships are highly sought after they have become the go-to fellowships and indeed we're very proud of that it's relatively uncommon for physicians in India to move to pure basic science research India lines has been extremely helpful for physician scientists they're very flexible in the way that one can work with them in terms of funds and buy equipment etc don't have these rigid walls and there's always somebody to talk to it communicated I'm stationed in Delhi and this community is in hard I needed to have a team both with me here as well as there in the field so for that I needed a comprehensive support all these will be supported by India lines which is like wonderful in a country like India where research is funded primarily through public funds the public has a right to know what scientists do wrong science communication builds scientific temper and also inspires the next generation of scientists DBT welcome trust in the Alliance program is completing ten years now we would love to see this expanding we like to see University is becoming a part of it and see these fellows at different levels being able to bring in the more and more PhD students and other researchers to build capacities in India for cutting edge research and bringing India into the forefront of biotechnology nobody has really so I'm delighted we got this far and done so well the springboard to the shoot you you

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